ea0020p479 | Obesity and Metabolism | ECE2009
Gormsen Lars C
, Host Christian
, Gravholt Claus
, Christiansen Jens S
, Nielsen Soren
Background: Hormone replacement therapy (HRT) in post-menopausal women carries an increased risk of cardiovascular disease due to an unfavorable effect on lipid profile. Thus, HRT treatment increases concentrations of very-low-density-lipoprotein-triglycerides (VLDL-TGs) which have been demonstrated to possess atherogenic properties. However, the exact mechanisms whereby VLDL-TG concentrations are increased by estradiol are not fully understood. Estradiol acts on both rapid re...